"Glutamine is considered the most important nutrient for healing of ‘leaky gut syndrome’ because it is the preferred fuel for enterocytes and colonocytes.
Low level of serum Glutamine concentration correlated with intestinal barrier disruption, inflammation and diarrheal diseases among children.
Glutamine supplementation causes a profound improvement in intestinal barrier function in highly stressed patients and patients in TPN.
Glutamine-fortified parenteral and enteral diets significantly improve the intestinal morphology and function.
Leaky gut or increased intestinal epithelial permeability has been implicated in the pathogenesis of several gastrointestinal diseases such as food allergies, IBD and IBS.
Glutamine is likely a potential intervention strategy for these diseases, as it reduces intestinal permeability from various stressors and helps maintain the normal intestinal barrier function"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/
Dietary sources of glutamine include plant and animal proteins such as beef, pork, poultry, milk, yogurt, ricotta cheese, cottage cheese, raw spinach, raw parsley, and cabbage.
https://www.youtube.com/watch?v=x5Zl8Cp8l3M
The most important nutrients for your immune system:
1. Vitamin A
- It is especially important to support healthy lungs
- It helps you make antibodies
- It increases T helper cells
The best sources of vitamin A:
- Grass-fed butter
- Egg yolks
- Liver
2. Vitamin E
- It helps protect against collateral damage
- It strengthens the T cells and phagocytes
The best sources of vitamin E:
- Grass-fed butter
- Leafy greens
- Nuts
- Egg yolks
3. Vitamin D
- It influences every part of the immune system
- It helps calm down an overactive immune system
- It helps shorten the duration of infection
The best sources of vitamin D:
- Grass-fed butter
- Cod liver oil
- The sun
- Supplements
4. Vitamin C
- It helps increase resistance to pathogens
- It helps protect against collateral damage
- It increases neutrophils
The best sources of vitamin C:
- Raw sauerkraut
- Leafy greens
- Grass-fed and grass-finished beef or liver
5. Zinc
- Without zinc, many things can’t work in the body
- It allows the thymus to make T cells
The best sources of zinc:
- Shellfish
- Eggs
- Red meat
6. Selenium
- It helps make glutathione
- It helps the immune system fight pathogens
- It helps protect against collateral damage
The best sources of selenium:
- Seafood
- Brazil nuts
7. Copper
- It helps protect against infections
- It helps protect against collateral damage
- It’s involved in immune system function
The best sources of copper:
- Shellfish
- Seafood
- Beef
- Meat
- Eggs
Plant Toxins cause Inflammation
Lectins - highest levels in whole grains such as wheat, raw legumes (beans, lentils, peas, soybeans, peanuts). Found in all plants. Can interfere with absorption of minerals (calcium, iron, phosphorus, zinc) and legumes and cereals often contain these so can prevent the absorption and growth of intenstinal flora. Lectin proteins bind for a long time, can cause autoimmune response and play a role in inflammatory conditions like rheumatoid arthritis and diabetes. Cooking, wet, high-heat such as boiling can inactivate most lectins. Water soluable and Typically found on the outer surface of food and so water removes them. Associated with lower rates of cardiovascular disease weight loss and type 2 diabetes. Rich sources of B vitamins, protein, fiber and minerals so their consumption outways their harm.
- Phenolics - apple
- Cyanogenic Glycosides - peach
- Oxalates - spinach
- Saponins - beans
- Glycoalkaloids - potatoe
- Endocrine disruptors
Phytic Acid - found in plant seeds. Prevents the absorption of iron, zinc, calcium. Soaking in water, sprouting of seeds grains and legumes, and Lactic Acid fermentation breakdown phytic acid (sourdough).
https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/
Food Milligrams (mg) per serving Percent DV* Beef liver, pan fried, 3 ounces 2.9 223 Breakfast cereals, fortified with 100% of the DV for riboflavin, 1 serving 1.3 100 Oats, instant, fortified, cooked with water, 1 cup 1.1 85 Yogurt, plain, fat free, 1 cup 0.6 46 Milk, 2% fat, 1 cup 0.5 38 Beef, tenderloin steak, boneless, trimmed of fat, grilled, 3 ounces 0.4 31 Clams, mixed species, cooked, moist heat, 3 ounces 0.4 31 Almonds, dry roasted, 1 ounce 0.3 23 Cheese, Swiss, 3 ounces 0.3 23 Mushrooms, portabella, sliced, grilled, ½ cup 0.2 15 Rotisserie chicken, breast meat only, 3 ounces 0.2 15 Egg, whole, scrambled, 1 large 0.2 15 Quinoa, cooked, 1 cup 0.2 15 Bagel, plain, enriched, 1 medium (3½"–4” diameter) 0.2 15 Salmon, pink, canned, 3 ounces 0.2 15 Spinach, raw, 1 cup 0.1 8 Apple, with skin, 1 large 0.1 8 Kidney beans, canned, 1 cup 0.1 8 Macaroni, elbow shaped, whole wheat, cooked, 1 cup 0.1 8 Bread, whole wheat, 1 slice 0.1 8 Cod, Atlantic, cooked, dry heat, 3 ounces 0.1 8 Sunflower seeds, toasted, 1 ounce 0.1 8 Tomatoes, crushed, canned, ½ cup 0.1 8 Rice, white, enriched, long grain, cooked, ½ cup 0.1 8 Rice, brown, long grain, cooked, ½ cup 0 0
https://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq
https://www.sciencedirect.com/science/article/pii/S2213231720302123
Ascorbic acid (synthetic vitamin C) is made from glucose and other chemicals. Personally, I would only take ascorbic acid for a short-term detox cleanse, not on a long-term basis.
The best type of vitamin C to get is vitamin C from food or food-based vitamins.
Foods that have the most vitamin C: recommend 90mg/day
- SauerKraut - 700mg/cup
- Leafy greens
- Berries (blueberries 14.4g/c)
- Strawberries 85mg/c
- Tangerine - 52mg/c
- Orange - 96mg/c
- Mango 128mg/fruit
- Papaya - 95mg/fruit
- Lemons - 2 lemons - -6 oz 90mg most is in the zest
- Organ meats
- Bell peppers - 1 has 90 mg
- Cabbage - 30 mg/c
Things you need to know about vitamin C:
- There is little to no benefit from taking high doses of ascorbic acid.
- Most vitamin C sold is fake and made from sugar.
- Vitamin C is not absorbed well if you consume sugar at the same time.
- A mega-dose of ascorbic acid may cause oxidation, diarrhea, and bloating.
Vitamin C's role in immune function, in particular, is crucial. It stimulates the production of white blood cells, especially neutrophils, lymphocytes, and phagocytes, and promotes the cells' normal functions, such as their ability to detect, move toward, and engulf pathogens. Immune cells release large quantities of reactive oxygen species, often incurring damage. To protect themselves from this damage, immune cells accumulate large quantities of vitamin C, which serves as an antioxidant within the cells. Immune cells also release interferons, a class of proteins produced as a defensive response to viruses. Some evidence indicates that vitamin C promotes the production of interferon, a protein that participates in antiviral activity.[1] https://www.foundmyfitness.com/topics/vitamin-c
-
Vitamin A = immunity (viruses), eye health, helps iodine absorption
-
Vitamin B1-B3 = energy
-
Vitamin B5 + B6 = neurotransmitters
-
Vitamin B7 = hair & nails
-
Vitamin B12 = blood cells
-
Vitamin C = collagen
-
Vitamin D = Bone, immune, Blood Pressure, Pain - made by your skin, helps calcium absorption
-
Vitamin E = antioxidant, neurological, muscle, heart, arteries,
-
Vitamin K1 = Clotting, DNA
-
Vitamin K2 = arteries, Calcium transport
-
Inositol = Sleep
-
L-theanine = Calm
-
Magnesium = Relax
-
B-Complex = Energy
-
Vitamin D3 = Immunity
-
Chromium = Blood sugar
-
Vitamin K2 = Heart health
-
Blackseed oil = Immunity
-
Cod liver oil = Allergies
-
Creatine = Muscle
-
Collagen = Joints
-
Fish oil = Inflammation
Earliest signs of nutritional deficiencies
-
Vitamin A - Difficulty seeing in the dark
-
Vitamin B1 - Nervous tension
-
Vitamin C - Swollen or red gums with slight bleeding
-
Vitamin D - Bone pain
-
Vitamin E - Muscle weakness
-
Vitamin K1 - Excessive bruising
-
Vitamin K2 - Tartar buildup
-
Calcium - Chronic cough
-
Iodine - Breast tenderness
-
Sodium - Overall weakness
-
Magnesium - Loss of energy
-
Potassium - Pounding in your ears when trying to sleep
-
Selenium - Brain fog
-
Zinc - Getting out of breath upon exertion
98% of vitamins are synthetic, and most come from china and have questionable regulation and they use petroleum products. Therefore, Supplements should not be taken on a regular basis for health but periodic detox is ok. Supplements have traces of industrial chemicals chloroform, petroleum, methonal, formic acid, Toulene, herbicides, hexane and none of these are found in nature
Best source of vitamins are from food.
Microbes in gut make some of the vitamins.
Bio-availability is lost when using supplements. Shown in numerous clinical trials.
Nature makes sure these are grouped together to better deal with free radicals.
Vit-c decreases muscle mitochondria and muscle training efficiency.
Retinol - best form of Vit-A
Beta-Carotene- unfortunately only a tiny bit of Vit-A gets absorbed
https://chrismasterjohnphd.com/blog/2019/03/06/vitamins-minerals-101
Vitamins to take as you get older
- Vitamin C - loser histamine, help with cancer
- Vitamin B3 Niacin - 500-1000mg
- Magnesium
- Vitamin D - 10,000 iU
- Vitamin K1
- Vitamin K2 energy
B complex vitamins
https://www.healthline.com/nutrition/vitamin-b-foods#TOC_TITLE_HDR_5
Many foods are high in B vitamins, including certain types of meat, fish, and poultry, legumes, seeds, eggs, dairy products, and leafy greens.
Some top sources of B vitamins include meat (especially liver), seafood, poultry, eggs, dairy products, legumes, leafy greens, seeds, and fortified foods, such as breakfast cereal and nutritional yeast.
If you restrict your intake from some food groups due to allergies or diet, your chances of B vitamin deficiencies may increase.
Produce energy and make important molecules. All, except B12 are short-lived.
- thiamine (B1)
- riboflavin (B2)
- niacin (B3)
- pantothenic acid (B5)
- pyridoxine (B6)
- biotin (B7)
- folate (B9)
- cobalamin (B12)
https://c19vitamind.com/cavd.html
https://www.melatonin-research.net/index.php/MR/article/view/19/150
https://www.youtube.com/watch?v=ha2mLz-Xdpg
https://www.youtube.com/watch?v=5YV_iKnzDRg
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial
Vit-D acts as a hormone more than a vitamin. Helps with inflammation, involved with the immune system
The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759203/
Make your own Vit D2
Mushroom gills exposed to UVB light boost 5000IUs to 46,000 IUS
Also have Seleniu, Zinc, Copper Vit-C
Oyster, shitake, button (slice lengthwise) suate in butter for better absorption
sunny days (jun-aug ) - point gills up on tray from 10am-6pm two days, if still not dry use dehydrator to finish (snap in half and pretty crisp) place in sealed glass jar with a few rice grains to absorb moisture and good for one year
uvb light for 18 hours an 100g or cup gives you 46,000 IUs if sundried, 200,000 ius if uvb light button mushrooms only give about 20,000 IUs
Autoimmune triggers:
- A vitamin D deficiency
- A virus, bacteria, or pathogen
- Exposure to something that weakens your immune system
- Stress
- The wrong diet
- A genetic weakness
Even though various factors can lead to an autoimmune disease, vitamin D deficiency is at the heart of this condition.
Top causes of a vitamin D deficiency:
• A genetic weakness
• Obesity
• Insulin resistance
• Darker skin
• Less exposure to the sun
• Aging
Vitamin D controls the immune system, and it can either boost or suppress certain parts of the immune system.
Inflammation is also a key factor involved in autoimmune disorders, but there are important things you can do to turn off the inflammatory process.
The best natural remedies for autoimmune conditions: • Vitamin D • Omega-3 fatty acids (while avoiding omega-6 fatty acids) • Cod liver oil • Curcumin • Blueberries (C but no D) • Maitake mushrooms • St. John’s wort
Vitamin D, Blueberries, and Grapes: Partners in the Immune System? Posted on November 15, 2013 by Alexander Michels, PhD
Blueberries - can they work with vitamin D?
Part of a healthy immune system involves responding to bacterial invasion. The body has many mechanisms to combat bacteria, including the white blood cells or leukocytes.
Several types of white blood cells produce small strings of amino acids (that are typically referred to as ‘peptides’) that can target invading bacteria. Through a variety of mechanisms, these peptides can associate with a bacterial cell membrane, breaking the cell open and driving it toward death. Collectively, these are known as “antimicrobial peptides”.
Here’s where vitamin D gets involved:
One of these antimicrobial peptides is known as cathelicidin. What makes cathelicidin unique among these peptides is that the gene associated with it (known as CAMP for Cathelicidin Antimicrobial Peptide) is regulated by vitamin D. Providing vitamin D to leukocytes promotes the expression of CAMP and to increase their bacteria-killing activities.
Regulation of the CAMP gene, especially in context of vitamin D, has been a central question driving the research of Adrian Gombart, PhD, at the Linus Pauling Institute for many years. Recently, he spearheaded an effort at LPI to look for additional small molecules that may work alongside vitamin D to regulate cathelicidin production.Fritz in lab
Their two-step approach involved some genetic manipulation in cells. First, they fused the promoter (a region of DNA that regulates expression of a gene) from the human CAMP gene to another gene that makes a protein called a ‘transcriptional activator.’ The transcriptional activator, if produced, then turned on the production of an enzyme called firefly luciferase. The end result is simple: if any compound added to cells activated CAMP, the cells would glow like a firefly.
Dr. Gombart and his research team then screened 446 different molecules that are currently being tested in clinical trials by the NIH. At the end of the process they found two molecules that not only promoted CAMP gene expression but also worked in combination with vitamin D! Even more interesting, these compounds were normal dietary components: resveratrol (found in red grapes and red wine) and pterostilbene (found in blueberries).
Neutrophil and Bacteria “Out of a study of hundreds of compounds, just these two popped right out,” said Dr. Gombart, who is an LPI principal investigator and an associate professor in the Biochemistry and Biophysics department at Oregon State University. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It’s a pretty interesting interaction.”
Does this mean drinking red wine and eating blueberries, along with taking vitamin D, will increase your innate defense against invading bacteria? Unfortunately, we don’t know yet. Dr. Gombart’s lab is working hard on determining how these compounds work in the immune system and whether they can boost cathelicidin levels in leukocytes.
There are plenty of other reasons to enjoy a glass of red wine, eat a handful of blueberries, and get your vitamin D. As for improving your immune response, that would just be a bonus!
Vitamin D and Covid-19 https://chrismasterjohnphd.substack.com/p/my-response-to-rhonda-patrick-on
magnesium activates Vit D? needs to be taken together. Also K2
There is a powerful form of testosterone in the body called DHT. Testosterone can convert to DHT with a specific enzyme. Certain medications inhibit this enzyme to reduce DHT and help with male pattern baldness, prostate hypertrophy, and erectile dysfunction. But, zinc is actually a natural inhibitor of this enzyme.
Zinc is the most important nutrient to support a high testosterone level, sperm fertility, and a healthy prostate.
The prostrate gland has 100x as much zinc as can be found in your blood.
A zinc deficiency could lead to an enlarged prostate gland, inflammation of the prostate gland, and an increased risk of prostate cancer. A zinc deficiency can also affect your libido, testosterone, sperm count, and urine flow.
Causes of a zinc deficiency:
- Not consuming enough red meat
- Low stomach acid
- Certain medications (antacids, diuretics, statins)
- Alcohol
- Sugar consumption
- Frequent meals (insulin resistence)
Foods high in zinc:
- Shellfish
- Red meat
You could also take a zinc supplement. However, zinc alone will not act as a cure for an enlarged prostate or other medical conditions because there are many other factors involved. One of these factors is your diet. Keto and intermittent fasting.
While Zinc is the mineral oriented component in better regulation of DHT (and thus optimal prostate health and even hair loss prevention), there is also a notable mention to essential fatty acids. Alpha Linolenic Acid (ALA) and Gamma Linolenic Acid (GLA) are superb in DHT regulation, so essentially, anyone who is not getting enough essential fatty acids in their diet (or supplementation), is going to experience overproduction of DHT, especially when aging becomes a factor. There are a few studies relating to regular consumption of avocado (for example) being a powerhouse DHT regulating food, for exactly this reason (the essential fatty acid connection to DHT regulation). In herbal medicine, the “tried and true” Saw Palmetto herbal supplement, has always been synonymous with both DHT regulation and prostate health.
Sources and Citations
"Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[1] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.
Zinc modulates numerous aspects of the immune system and is essential for proper immune function. Studies suggest that mild nutritional zinc deficiency (generally with serum zinc less than 70 micrograms per deciliter) impairs immune function due to decreased activity and regulation of the immune system.[70]
Clinical and mechanistic studies have shown that zinc deficiency can cause T cell dysregulation and decrease total T cell numbers.[71][72][73] T cells are immune cells that play important roles in both destroying pathogens and regulating the immune response."
"An enlarged prostate can affect urination and libido. The more the prostate enlarges, the higher your risk is for prostate cancer. But, just because the prostate enlarges doesn’t mean you have cancer.
Many studies have investigated the relationship between serum zinc concentration and prostatic disease, but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the correlation between serum zinc concentration and prostate disease. Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, MEDLINE, CNKI and the Cochrane Library up to June 2015 for studies that involved the relationship between serum zinc concentration and prostate disease. Fourteen studies were identified from the databases.
Our results illustrated that the serum zinc concentrations in prostate cancer patients were significantly lower than those in Benign prostatic hyperplasia (BPH) patients and normal controls (SMD (95% CI), −0.94 [−1.57, −0.32]; −1.18 [−1.90, −0.45]). However, the serum zinc concentrations in BPH patients were significantly higher than those in normal controls (SMD (95% CI) 1.77 [0.15, 3.39]). The present study showed that different levels of serum zinc concentrations are correlated with different prostatic disease. Serum zinc concentration may be used as a tool for the diagnosis and screening of prostate disease. But, further studies with well-designed larger sample studies are needed in this field to further clarify the correlation between serum zinc concentration and prostate disease."
"Research has been consistently showing the role of zinc (Zn) in prostate function. In this article, we review the current literature on the anatomy and main functions of the prostate, highlighting the role of zinc. In particular, we will review the etiology of benign prostate enlargement (BPH), its prevalence in men over 50, the likelihood of BPH becoming prostate cancer (PCa), and explain the relationship of zinc and apoptosis in the prostate cells and the implications for BPH and PCa.
We present a model that explains how endogenous factors provoke excretion of zinc or limit zinc absorption, and how exogenous factors like nutrition and drugs regularly used in men over 50 can significantly decrease zinc status and thereby increase the risk of BPH. Finally, we explain how Zn amino acid (AA) complexes may be capable of avoiding antagonists and inhibitors of zinc absorption, thereby increasing the bioavailability of zinc for the necessary biological processes in the prostate."
Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders