vitamin d

Jul 21, 2023
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https://c19vitamind.com/cavd.html

https://www.melatonin-research.net/index.php/MR/article/view/19/150

https://www.youtube.com/watch?v=ha2mLz-Xdpg

https://www.youtube.com/watch?v=5YV_iKnzDRg

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial

https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbDVPei16dzVSejZ1blduV1JhSWxNWm5LRVVGQXxBQ3Jtc0trMzlMU2IydXkxTTk4OEtBdHNGcE5ydFNpMjFvVlpHM01sMExNSVdSWXZDSEVkT2FsLTRubHJ0YnBaZWVKZHRDTC1vLVcwUDVPUlN1RGdjT25RSnJ5MDZueHdQOFI4WTZpbkRlc3U1ZW9FNkJ4OGFITQ&q=https%3A%2F%2Fwww.bmj.com%2Fcontent%2Fbmj%2F376%2Fbmj-2021-066452.full.pdf

Vit-D acts as a hormone more than a vitamin. Helps with inflammation, involved with the immune system

The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759203/

Make your own Vit D2

Mushroom gills exposed to UVB light boost 5000IUs to 46,000 IUS

Also have Seleniu, Zinc, Copper Vit-C

Oyster, shitake, button (slice lengthwise) suate in butter for better absorption

sunny days (jun-aug ) - point gills up on tray from 10am-6pm two days, if still not dry use dehydrator to finish (snap in half and pretty crisp) place in sealed glass jar with a few rice grains to absorb moisture and good for one year

uvb light for 18 hours an 100g or cup gives you 46,000 IUs if sundried, 200,000 ius if uvb light button mushrooms only give about 20,000 IUs

Autoimmune triggers:

  1. A vitamin D deficiency
  2. A virus, bacteria, or pathogen
  3. Exposure to something that weakens your immune system
  4. Stress
  5. The wrong diet
  6. A genetic weakness

Even though various factors can lead to an autoimmune disease, vitamin D deficiency is at the heart of this condition.

Top causes of a vitamin D deficiency: • A genetic weakness • Obesity • Insulin resistance • Darker skin
• Less exposure to the sun • Aging

Vitamin D controls the immune system, and it can either boost or suppress certain parts of the immune system.

Inflammation is also a key factor involved in autoimmune disorders, but there are important things you can do to turn off the inflammatory process.

The best natural remedies for autoimmune conditions: • Vitamin D • Omega-3 fatty acids (while avoiding omega-6 fatty acids) • Cod liver oil • Curcumin • Blueberries (C but no D) • Maitake mushrooms • St. John’s wort

Vitamin D, Blueberries, and Grapes: Partners in the Immune System? Posted on November 15, 2013 by Alexander Michels, PhD

Blueberries - can they work with vitamin D?

Part of a healthy immune system involves responding to bacterial invasion. The body has many mechanisms to combat bacteria, including the white blood cells or leukocytes.

Several types of white blood cells produce small strings of amino acids (that are typically referred to as ‘peptides’) that can target invading bacteria. Through a variety of mechanisms, these peptides can associate with a bacterial cell membrane, breaking the cell open and driving it toward death. Collectively, these are known as “antimicrobial peptides”.

Here’s where vitamin D gets involved:

One of these antimicrobial peptides is known as cathelicidin. What makes cathelicidin unique among these peptides is that the gene associated with it (known as CAMP for Cathelicidin Antimicrobial Peptide) is regulated by vitamin D. Providing vitamin D to leukocytes promotes the expression of CAMP and to increase their bacteria-killing activities.

Regulation of the CAMP gene, especially in context of vitamin D, has been a central question driving the research of Adrian Gombart, PhD, at the Linus Pauling Institute for many years. Recently, he spearheaded an effort at LPI to look for additional small molecules that may work alongside vitamin D to regulate cathelicidin production.Fritz in lab

Their two-step approach involved some genetic manipulation in cells. First, they fused the promoter (a region of DNA that regulates expression of a gene) from the human CAMP gene to another gene that makes a protein called a ‘transcriptional activator.’ The transcriptional activator, if produced, then turned on the production of an enzyme called firefly luciferase. The end result is simple: if any compound added to cells activated CAMP, the cells would glow like a firefly.

Dr. Gombart and his research team then screened 446 different molecules that are currently being tested in clinical trials by the NIH. At the end of the process they found two molecules that not only promoted CAMP gene expression but also worked in combination with vitamin D! Even more interesting, these compounds were normal dietary components: resveratrol (found in red grapes and red wine) and pterostilbene (found in blueberries).

Neutrophil and Bacteria “Out of a study of hundreds of compounds, just these two popped right out,” said Dr. Gombart, who is an LPI principal investigator and an associate professor in the Biochemistry and Biophysics department at Oregon State University. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It’s a pretty interesting interaction.”

Does this mean drinking red wine and eating blueberries, along with taking vitamin D, will increase your innate defense against invading bacteria? Unfortunately, we don’t know yet. Dr. Gombart’s lab is working hard on determining how these compounds work in the immune system and whether they can boost cathelicidin levels in leukocytes.

There are plenty of other reasons to enjoy a glass of red wine, eat a handful of blueberries, and get your vitamin D. As for improving your immune response, that would just be a bonus!

Vitamin D and Covid-19 https://chrismasterjohnphd.substack.com/p/my-response-to-rhonda-patrick-on

magnesium activates Vit D? needs to be taken together. Also K2

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